Areas of work of the department

The department's research is aimed at solving the following scientific and technical problems and tasks:

1. physicochemical design and study of new coordination compounds to create new substrates for medical (anticancer and antiviral drugs) and technical applications (olefin oxidation catalysts, photovoltaic devices):
- with pharmacophore groups - organic molecules related to living organisms: heterocycle-containing carbothioamides, hydroxyimines, derivatives of complex esters of β-keto acids, β-enamino esters, hydroxamic and bisphosphonic acids with biogenic (Fe3+, 2+, Co2+, Ni2+, Cu2+, Zn2+, V4+, V5+) and pharmaceutically important (Ru3+, Rh3+, Pd2+, Pt2+, Ag+) d-metals;
- of macrocyclic systems based on phthalocyanine complexes related to biologically active porphyrins and three-dimensional clathrochelate cage complexes;

2. selection of the most promising compounds for use in industry and pharmaceutics

History of the department

The Department of the Chemistry of Complex Compounds was founded in 1947. In different years, the department was headed by Corresponding Members of the Ukrainian Academy of Sciences, Doctor of Chemistry V.Y. Izbekov, I.A. Sheka and Doctor of Chemistry Y.A. Maletin (1987-2001). The Department was once staffed by world-renowned scientists Academician K.B. Yatsymirskyi and Doctor of Chemistry N.A. Kostromina.

The department has always focused on the chemistry of aqueous and non-aqueous solutions of simple and complex compounds, including synthesis, properties of complexes, complexation equilibria, structure of complexes, purification of synthesized compounds, spectral methods, bioinorganic chemistry, development of technologies for purification of rare elements, and recently medical chemistry.

The methods of purification of zirconium oxide and improvement of hafnium production, processes for the production of indium and metal powders of zirconium and niobium developed under the leadership of I.A. Sheka were widely used at enterprises of the Ukrainian SSR. The developments were awarded the State Prize of the USSR in Science and Technology (1986), and I.A. Sheka was awarded the Order of the Red Banner of Labor.

Zimergakl and I.A. Sheka

Corresponding Member of the National Academy of Sciences of Ukraine, Head of the Department I.A. Shek

Fertilizers based on metal complexonantes, developed under the leadership of N.A. Kostromina have also found their application. Preparations were proposed, tested and put into production that increase seed formation and the productivity of alfalfa, as well as the yield of grapes, fruit crops and cotton. the works to create of biologically active drugs were awarded medals of VDNKh of the USSR. In 2003, N.A. Kostromina was among the first women in Kyiv to be awarded the Order of Princess Olga, III grade.

Former employees of the department are now working fruitfully at the universities of Dresden and Vienna and at pharmaceutical companies in Ukraine.

Since 2002, the department has been headed by V.I. Pekhnyo, Member of the Ukrainian National Academy of Sciences, Doctor of Chemistry Sciences, Professor, Honored Scientist and Technologist, Laureate of the State Prize of Ukraine in Science and Technology, Honorary Doctor of Uzhhorod National University.

With the arrival of V.I. Pekhnyo, the scope of the department's work was significantly expanded. One of the main directions was the development of physicochemical approaches to the creation of new functional materials based on coordination compounds with predictable composition, structure and properties:
- Methods for the synthesis of hundreds of new coordination compounds have been developed, and the regularities of the relationship between the conditions of their synthesis, structure, and functional properties have been established.
- New molecular, ionic mono-, heterometallic (heteronuclear), heteroligand coordination compounds of 3d and platinum metals with polydentate functionalized derivatives of carbon chain heterocyclic aromatic organic molecules wave been modeled, experimentally obtained, and spectrally and structurally characterized.
- New complexes of platinum and a number of 3d metals with derivatives of diphosphonic acid` modified with amino, hydroxy groups, heterocyclic fragments of the structure; amino acid derivatives and with nitrogen- and sulfur-containing heterocyclic, aromatic derivatives of oximes, hydroxyimines, iminothiazoles, allyl-containing thiosemicarbazones as a potential basis for the treatment of certain cancer, virus, cardiovascular diseases and diabetes, technical composites, lubricants and magnetic materials, have been synthesized and investigated.

Doctor of Chemical Sciences S.I. Orysyk.

Associate Professor, Candidate of Chemical Sciences O.M. Kozachkova

- Together with scientists from the R.E. Kavetskyi Institute of Experimental Pathology, Oncology and Radiobiology of the Ukrainian National Academy of Sciences, the cytotoxic activity of solutions of Pd complexes with OEDP in vivo and in vitro against Erich's carcinoma and L1210 lymphatic leukemia was found to be equal to that of cis-platin and at the same time with significantly lower nephrotoxicity. The selective accumulation of palladium in animal bones was found, which demonstrated the targeted delivery of the cytostatic agent to the target - tumor-affected bones.
- A number of new lipophilic complexes of biometals - Zn(II), Mo(VI), Cu(II), Co(II) and Ni(II)- with derivatives of -keto-, hydroxamic acids modified with hydrophobic substituents have been obtained; the complexes are promising as additives to biobased lubricants.

- All developed synthesis methods can be quickly adapted to mass production if necessary.
- A method has been developed for determining the induction period of oxidation, which is the time interval between the moment when the sample reaches a given temperature (110 C) and the moment when the oxidant (O2) pressure in a sealed measuring system begins to drop sharply. The advantage of the developed method is the combination of relatively cheap mass-produced components and conventional computer software in the new measuring system, which allows obtaining test results that are superior, according to the convergence criterion, to those obtained by standardized methods - analogues. The developed method and device also favorably differ from analogues in that they allow to realize the kinetic mode of oxygen absorption by the sample both in a homogeneous solution and in a heterophase liquid system with dispersed substrate. The developed method can be used in laboratories for fat and oil production, food and pharmaceutical industries, chemical plants, and research institutions.

In 2017, a non-structural laboratory of macrocyclic compounds and hybrid structures was included in the department. The laboratory was established under the guidence of Doctor of Chemistry O.A. Varzatskyi in 2010 at the Department of Physical and Inorganic Chemistry. Since 2018, the laboratory has been headed by Doctor of Chemistry V.Y. Chernii.

I.M. Denisenko.

I.M. Tretyakova

К.х.н. S.V. Vakarov

Head of the laboratory V.Y. Cherniy

The main research area of the laboratory is solving topical problems of coordination chemistry: synthesis of macroheterocyclic complexes, in particular, phthalocyanines and clathrochelates of p-, d- and f-metals and studies by physical and chemical methods such as NMR, X-ray analysis, mass spectrometry, electron absorption spectroscopy, and stationary fluorescence spectroscopy.

The main tasks of the laboratory:
- template synthesis of macrocyclic transition metal complexes;
- exchange processes of metal ions and axial out-of-plane ligands in macrocyclic complexes;
- development of synthetic methods for the modification and functionalization of macrocyclic ligands, metal-promoted reactions of coordination compounds;
- synthesis of catalytic and redox-active metal complexes;
- studying the properties of macrocyclic metal complexes, searching for promising areas of their application, in particular, for the creation of functional nano-materials and biologically active compounds.

At present, the laboratory's efforts are focused on the preparation and study of the properties of iron (II) clathrochelates with functional terminal groups and multichromophore systems based on phthalocyanines and clathrochelates with chromophore ligands coordinated to the central metal atom, including condensed dehydroacetic acid derivatives, styrylcyanines, curcuminoids, etc. and investigation of their properties.

Today, the department and laboratory employ 3 Doctors of Science, 4 Candidates of Science, 1 junior researcher, 4 leading engineers, 2 process engineers, and 1 graduate student.

Modern composition of the department

Head of the department
	Vasily Ivanovich Pekhnyo
Leading researcher
	Orysyk Svitlana Ivanovna
Senior researcher
	Kozachkova Oleksandra Mykolaivna
Researcher
	Koval Liudmyla Ivanivna
Junior researchers
	Olena Ludvigivna Ilnytska
Leading process engineers
	Borovyk Polina Vladimirovna		Valery Ivanovich Dziuba		Olgerd Oleksandrovych Stockvysh

Leading researcher
	Cherniy Viktor Yaroslavovych
Senior researchers
	Irina Nikolaevna Tretyakova		Chornenka Nina Vasylivna
Leading process engineers
	Sergey Vasilyevich Vakarov		Fedosova Natalia Nikolaevna
Process engineer of the 1st category
	Roman Oleksandrovych Selin

Implemented projects of the department

International projects:

1 - Marie Curie Action FP7-PEOPLE-2011-IRSES "International Exchange of Scientific Personnel" - Project No. 295160 "Design and development of new topological drugs based on cellular compounds" (2011-2015).

2 - EU Program "Horizon 2020". Marie Curie Action "International Exchange of Scientific Personnel" Project №645628 - METCOPH - MSCA-RISE "Metal complexes of macrocyclic compounds for photonic devices" (2015-2018).

3 - STCU Project #2080 (together with Department #2) Development of ceramic semiconductor composites based on ternary spinels of nickel, cobalt, manganese and copper. Scientific adviser: Professor, Doctor of Chemistry Sciences V.I. Pekhyo, 2000-2002.

4 - STCU Project No. 5508 "Development of macrocyclic metal complexes - inhibitors of amyloid fibril formation causing neurodegenerative diseases" (2011-2013).

5 - STCU project No. 5972 "Development of macrocyclic metal complexes for the photo-induced destruction of insoluble protein aggregates formed in neurodegenerative diseases" (2014-2016).

6 - No. 3213 (together with department No. 2) "Development of ceramic semiconductor composites based on ternary spinels of nickel, cobalt, manganese and copper". Manager: Professor V.I. Pekhnyo, 2005-2006.

7 - STCU project 4120 "New nanomaterials for thin-film solar cells based on complex chalcogenides - synthesis, chemical analysis and spectral characterization" (2007-2008)

8 - STCU project 5204 "Low-energy controlled synthesis of time-stable nanopowders of oxides, chalcogenides of Cu, Zn, Cd, Hg, etc. of a given dimension and morphology" (2010-2011);

9 - Bilateral agreement between the Ukrainian National Academy of Sciences and the Russian Foundation for Basic Research No. U 17-03-12 "Multifunctional and multicentered cage complexes with an encapsulated metal ion - precursors of topological drugs, diagnostic and pharmaceutical preparations" (2012).

10 - Project of the State Foundation for Basic Research of Ukraine and the Belarusian Republican Foundation for Basic Research "SBRF-BRFBR - 2011" (F41) - "Palladium(II) phosphonates in new technologies for the diagnosis and treatment of a number of cancer diseases".

11 - Joint project of the Ukrainian National Academy of Sciences and the Russian Foundation for Basic Research. "Chemical design of polynuclear metal-containing architectures with O-, N-, S-donor molecules and phosphonic acid derivatives" (2011)

12 - Project of the State Foundation for Basic Research of Ukraine and the Belarusian Republican Foundation for Basic Research "SBRF - BRFBR - 2013 (F54) - "Phosphorus-containing metal complexes in optical-physical and chemotherapeutic technologies for the early diagnosis and control of the effectiveness of treatment of malignant tumors".

National projects:

13 - "Physical and chemical basics of synthesis and spectral and structural characterization of multifunctional nanoscale coordination compounds of d-metals with heterocyclic bioligands - hydroxyimino thiazoles, thioureates and hydroxyimino acetates" - comprehensive target program of basic research of the Ukrainian National Academy of Sciences "Fundamental Problems of Nanostructured Systems, Nanomaterials, Nanotechnologies" (2011-2015).

14 - "Synthesis, structure and properties of nanoscale biologically active complexes of palladium(II) with amino phosphonic acids." - Program of fundamental research of the Ukrainian NAS "Fundamental problems of nanostructured systems, nanomaterials, nanotechnologies", (2011-2015).

15 - "Lipophilic coordination compounds as polyfunctional additives for new bio-based eco-friendly lubricant compositions" - comprehensive target program of fundamental research of the Ukrainian National Academy of Sciences "Fundamental problems of creating new substances and materials chemical industry" (2012-2016).

16 - "Multifunctional nanoscale coordination compounds of d-metals based on substituted thioureas and hydroxyimines" - comprehensive target program of fundamental research of the uKRAINIAN National Academy of Sciences "Fundamental problems of creating new nanomaterials and nanotechnologies" (2015-2018).

17 - "Nanocomposites based on palladium bisphosphonates and fullerene-containing silicas for the development of targeted anticancer drugs" F76 (2017-2018)

18 - "Development of nanoscale coordination compounds of transition and noble metals with functions of suppression of angiogen-dependent growth of malignant tumors in oncology" - comprehensive target program of basic research of the Ukrainian National Academy of Sciences "Fundamental problems of creating new nanomaterials and nanotechnologies" (2018-2019)

19 - F84 «Development of novel hydroxamate and thiourea complexes of noble metals with anticancer, antimetastatic and metabolic functions as precursors of new generation drugs with the suppressed resistance of pathogenic cells to their action», supported by presidential grant for doctors of science (2019)

20 - Regularities of complexation (synthesis, spectral and structural characterization) of multifunctional, heterometallic coordination compounds of precious and 3d metals with modified bioactive ligands (phosphonic, hydroxamic, amino acids, carbothiamides, etc.)", theme 291E of the Ukrainian National Academy of Sciences (2011-2015).

21 - "Synthesis and study of the properties of new β-ketoenol compounds and their metal complexes for the creation of optical materials and fluorescent probes" - comprehensive target program of basic research of the Ukrainian National Academy of Sciences "New functional substances and materials for chemical industry") (2017-2018)

22 - "Synthesis, spectral and luminescent properties of new alkylamino-beta-ketoenol compounds and metal complexes based on them for the creation of fluorescent probes of biomolecules and optical materials" - comprehensive target program of basic research of the Uktainian National Academy of Sciences "New functional substances and materials for chemical industry") (2019-2020)

23 - Center for the Study of Nanostructured Systems, Nanomaterials, and Nanotechnologies of the Ukrainian National Academy of Sciences, Contract No. 49 "Complex Project: Chemical and Electrochemical Synthesis, Structure and Properties of Hybrid Organic-Inorganic Liquid Crystalline and Heterostructured Metal and Semiconductor Nanocomposites" (2013-2014).

24 - Scientific and technical (innovative) projects of the Ukrainian National Academy of Sciences. Contract No. 43-14 "Synthesis of photoactive substances for the creation of highly ordered monomolecular layers with externally controlled optical and sorption properties" (2014).

25 - "Coordination, medical chemistry of mono-, bi-, heterometallic, mixed-ligand complexes of "metals of life" - Fe, Co, Cu, Mo and cytostatics - Pd, Rh, Ru, Ga with modified, biorelated and bioactive antineopeastic, antiviral, antiresorptive molecules.", Theme 309 E of the Ukrainian National Academy of Sciences (2016-2020)

26 - Topic 310E "New inorganic compounds and high-performance functional materials (physical and chemical basics of design, heterogeneous-heterophase synthesis, structure, properties)" (2017-2021).

27 - Agreement with Farmak JSC "Development of a method for the synthesis of 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) (CAS-[60239-18-1])" (2009-2010)

28 - "Determination of the biodegradability of petroleum products using infrared spectroscopy" - Research Institute of Oil Refining and Petrochemical Industry "MASMA" 2014

29 - Development of technical documentation for the creation of an experimental production complex for synthesis of ammonium perchlorate (AP) and an experimental production complex for the manufacture of the modified AP powders" - Refinement of technological processes at the stage of feasibility study. Development of initial data for the release of the project of the experimental production complex for the synthesis of ammonium perchlorate, Pivdenne Design Office.

30 - "Refinement of technological processes at the stage of feasibility study. Development of initial data for the release of the project of the experimental production complex for the synthesis of ammonium perchlorate" Pivdenne Design Office

31 - Development of a project for an and experimental research laboratory for the synthesis of AP Pivdenne Design Office.

Projects currently being implemented by the department

International projects:

- CRDF Global Agreement FSA3-19-65501-0-I "Development of chaperone mimetics based on phthalocyanine complexes for the prevention of temperature-induced fibrillation of proteins in the food industry"

- Contract 07-03-20 according to the results of the joint competition of scientific projects of the Ukrainian National Academy of Sciences and the National Academy of Sciences of Belarus in 2020 "Multichromophore phthalocyanine complexes for use as photosensitizers and efficient photoconverters"

National projects

- within the framework of the program "New functional substances and materials for chemical industry" "Synthesis, spectral and luminescent properties of new alkylamino-beta-ketoenol compounds and metal complexes based on them for the creation of fluorescent probes of biomolecules and optical materials"

- "Functionally oriented nanoscale heterostructures based on antiviral, antineoplastic and antibacterial transition metal compounds" - target program of basic research of the Uktainian National Academy of Sciences "Promising basic research and innovative developments of nanomaterials and nanotechnologies for the needs of industry, healthcare and agriculture" for 2020-2024

Awards of the department

State Prize of Ukraine in Science and Technology (V.I. Pekhnyo)

Honored of Scientist and Technologist of Ukraine (V.I. Pekhnyo)

Commemorative award in honor of the 100th anniversary of the Ukrainian National Academy of Sciences (V.I. Pekhnyo), 2018.

Certificate of Honor of the Cabinet of Ministers of Ukraine (V.I. Pekhnyo)

Certificate of Honor of the Ukrainian NAS (V.I. Pekhnyo)

Award of the Ukrainian National Academy of Sciences "Talent, Inspiration and Work" (S.I. Orysyk).

The most significant and cited articles

1. Orysyk S.I., Bon V.V., Obolentseva O.V., Zborovskyi Yu.L., Orysyk ..., Pekhnyo V.I., Staninets V.I., Vovk V.M. Synthesis, structural and spectral characterization of Zn(II) complexes, derived from thiourea and thiosemicarbazide // Inorganica Chimica Acta – Doi: 10.1016/j.ica.2011.10.027., Vol. 382 (2012) P. 127–138

2. Bon V.V., Orysyk S.I., Pekhnyо V.I., Volkov S.V. Square-planar 1:2 Ni(II) and Pd(II) complexes with different coordination mode of salicylaldehyde (4)-phenylthiosemicarbazone: Synthesis, structure and spectral properties // Journal of Molecular Structure – Doi: 10.1016/j.molstruc.2010.08.046, Vol. 984 (2010), P. 15-22

3. Bon V.V., Orysyk S.I., Pekhnyo V.I., Orysyk V.V. and Volkov S.V. Synthesis and Spectroscopic Investigations of Rh(III) and Pd(II) Complex Compounds with N-(pyridine-2-yl)-morpholine-4-carbothioamide // Polyhedron – Doi: 10.1016/j.poly.2007.01.042, Vol. 26 (2007) P. 2935-2941

4. Orysyk S.I., Bon V.V., Zholob O.O., Pekhnyo V.I., Orysyk V.V., Zborovskyi Yu.L., Vovk M.V. Novel Pd(II) coordination compounds involving 2-[(2-Hydroxyphenyl)methylene]hydrazine-N-(2-propenyl)-carbothioamide as a ligand or proligand: Synthesis, crystal structures and analytical application. // Polyhedron – Doi: Vol. 51 (2013) P. 211–221.

5. Orysyk S.I., Bon V.V., Pekhnyo V.I., Zborovskyi Yu.L., Orysyk V.V., Vovk M.V. Synthesis, structure and spectral characteristics of Ni(II), Pd(II) and Zn(II) complexes with N-(2-pyridinyl)morpholine-4-carbothioamide // Polyhedron – Doi: 10.1016/j.poly.2012.12.021, Vol.38 (2012) P. 15–25.

6. Orysyk S.I., Rybachuk L.N., Pekhnyo V.I., Korduban A.M., Buslaeva T.M. The formation of Ru (III) and Rh (III) chloro aqua complexes and tautomeric forms of carboxylic acid benzoylhydrazones for the synthesis of new coordination compounds promising for the practical use // Russian journal of inorganic chemistry – Doi: 10.1134/S0036023610070132, Vol. 38 (2010) P. 1075-1082

7. Orysyk S.I., Repich G.G., Bon V.V., Dyakonenko V.V., Orysyk V.V., Zborovskyi Yu.L., Shishkin O.V., Pekhnyo V.I., Vovk M.V. Novel Fe(III), Co(III), Ni(II), Cu(II) coordination compounds involving 2-[(2-hydroxyphenyl)methylene]hydrazine-N-(2-propenyl)-carbothioamide as ligand: Synthesis, crystal structures and spectral characteristics // Inorganica Chimica Acta – Doi: 10.1016/j.ica.2014.08.056, vol. 423, (2014) P. 496–503.

8. Repich H.H., Orysyk S.I., Orysyk V.V., Zborovskyi Yu.L., Melnyk A.K., Trachevskyi V.V., Pekhnyo V.I., Vovk M.V. Influence of synthesis conditions on complexation of Cu (II) with O, N, O tridentate hydrazone ligand. X-ray diffraction and spectroscopic investigations // Journal of Molecular Structure – Doi: 10.1016/j.molstruc.2017.05.140, Vol. 1146 (2017) P. 222–232.

9. Repich H.H., Orysyk V.V., Palchykovska L.G., Orysyk S.I., Zborovskyi Yu.L., Vasylchenko O.V., Storozhuk O.S., Biluk A.A., Nikulina V.V., Garmanchuk L.V., Pekhnyo V.I., Vovk M.V. Synthesis, spectral characterization of novel Pd(II), Pt(II) π-coordination compounds based on N-allylthioureas. Cytotoxic properties and DNA binding ability. // Journal of Inorganic Biochemistry – Doi: 10.1016/j.jinorgbio.2016.12.004, Vol. 168 (2017) P. 98-106

10. Repich H.H., Orysyk S.I., Orysyk V.V., Zborovskyi Yu.L., Pekhnyo V.I., Vovk M.V. Synthesis, crystal structure and spectral characterization of the first Ag+ complex compounds involving O, N, O-coordinated N-acylhydrazones of salicylaldehyde // Journal of Molecular Structure – Doi: 10.1016/j.molstruc.2017.05.024, Vol. 1144 (2017) P. 225-236

11. Orysyk S.I., Zholob O.O., Bon V.V., Nikulina V.V., Orysyk V.V., Nikolaenko T.V., Garmanchuk L.V., Zborovskyi Yu.L., Tolstanova G.M., Khranovskaya N.N., Pekhnyo V.I., Vovk M.V. Novel chelate complexes of Co(II), Ni(II), Cu(II), Pd(II) derived from anti- and syn-isomers of 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetic acid with pro-/antiproliferative actions on endothelial cells // Polyhedron – Doi: 10.1016/j.poly.2014.08.034, vol. 85 (2015) P. 208–220

12. Brovyk P.V. Litvinchuk B. Bentya A.V. Orysyk S.I. Zborovskyi Yu.L. Slyvka N. Yu. Orysyk V.V. Pekhnyo V.I. Vovk M.V. Complex of Zn(II) and Ag(I) with allyl thioamides of pyrimidinyl (cyclohexenyl) carboxylic acids and products of their proto - and iodocyclization// Ukrainian Chemistry Journal – Doi: 10.33609/0041-6045.85.3.2019.3-19, Vol. 85 (2019) P. 3-19

13. Ohenko V., Orysyk S., Kharkova L., Yanko O. Synthesis and spectral characteristics of promising nanosized carbon quantum dots for adsorption and catalytic processes // Ukrainian Chemistry Journal – Doi: 10.33609/0041-6045.86.1.2020.3-11, Vol. 86 (2020) P. 3-11

14. Borovyk P.V., Litvinchuk M.B., Bentya A.V., Orysyk S.I., Zborovskyi Y.L., Orysyk V.V., Pekhnyo V.I., Vovk M.V. Synthesis and spectral characteristics of Ru(III,II), Rh(III) and Pd(II) complexes with N-allyl thioamides and products of their proto- and iodocyclization // Ukrainian Chemistry Journal – Doi: 10.33609/2708-129X.86.4.2020.63-90, Vol. 86 (2020) P. 63-90

15. Orysyk S.I., Borovyk P.V., Repich H.H., Severynovska O.V., Zborovskyi Yu. L., Mishchenko A.M., Orysyk V.V., Pekhnyo V.I., Vovk M.V. Synthesis, spectral characterization and DFT calculations of novel Ag (I) π-coordination polymeric complexes based on N-allylmorpholine-4-carbothioamide // Journal of Molecular Structure – Doi: 10.1016/j.molstruc.2020.127866, Vol. 1208 (2020) P. 127866

16. Borovyk P.V., Orysyk S.I., Repich H.H., Likhanov A.F., Mishchenko A.M., Zborovskyi Yu.L., Orysyk V.V., Palchikovska L.G., Pekhnyo V.I., Vovk M.V. Spectral characteristics and cytostatic effect of Pd(II) and Pt(II) carbothioamide -complexes on Allium Cepa L Meristem cells // Voprosy Khimii i khimicheskoi Tekhnologii – Doi: 10.32434/0321-4095-2020-130-3-34-45, Vol. 130 (2020) P. 34-45

17. L.I. Koval, V.I. Dzyuba, O.L. Ilnytska, V.I. Pekhnyo Efficient transesterification of ethyl acetoacetate with higher alcohols without catalysts. // Tetrahedron Letters. -2008.-V 49, № 10, P. 1645-1647 (doi:10.1016/j.tetlet.2008.01.018).

18. L.I. Koval, V.I. Dzyuba, V.V. Bon, O.L. Ilnytska and V.I. Pekhnyo Synthesis and structure of anhydrous complexes of magnesium (II) with b-ketoesters of higher alcohols/ Polyhedron.- 2009.- V. 28.- P. 2698-2702 (doi:10.1016/j.poly.2009.05.034).

19. V.I. Dzyuba, L.I. Koval, V.V. Bon, V.I. Pekhnyo, Synthesis and structure of lipophilic dioxo-molybdenum (VI) bis(hydroxamato) complexes // Polyhedron.- 2010.- V. 29.- P. 2900 – 2906 (doi:10.1016/j.poly.2010.07.014).

20. Valerii I. Dzyuba, Lyudmila I. Koval, Anatolii V. Dudko & Vasyl I. Pekhnyo. N Hydroxyhomoazaadamantanone and its complexes with dioxomolybdenum(VI) and copper(II): synthesis and structure // Journal of Coordination Chemistry (Publisher: Taylor & Francis). – 2014. – V. 67, No. 8, 1437–1448 (http://dx.doi.org/10.1080/00958972.2014.910598).

21. Koval L.I., Dziuba V.I., Ilnytska O.L., Pekhnyo V.I., Mishchuk O.O.. Coordination compounds of life metals and bioligands as model additives to eco-friendly lubricant compositions // Khimiya Fizyka ta Tekhnolohiya Poverkhni, 2015. vol. 6, № 1. pp. 147 - 164.

22. Koval, L.I.; Dzyuba, V.I.; Pekhnyo, V.I. New method for evaluating the activity of antioxidants (method and substrate) //Kataliz i Neftekhimiya. - 2015. No. 24, - P. 65-69.

23. Shtokvysh O.O., Koval L.I., Pekhnyo V.I.. Synthesis and study of cobalt (II) complexes with acetoacetic acid esters of primary, secondary and tertiary alcohols // Ukr. Khim. Zhurn. - 2015. - Vol. 81, No. 12. - P. 92-98.

24. V.I. Dzyuba, L.I. Koval, V.I. Pekhnyo. An accessible method for the evaluation of the thermo-oxidative stability of organic substrates based on vegetable oils // Thermochimica Acta. – 2016. – V. 632. – P. 91 – 93 (http://dx.doi.org/10.1016/j.tca.2016.04.002).

25. Shtokvysh O.O., Koval L.I., Dyakonenko V.V., Pekhnyo V.I. // Structure of NI (II) complexes with cyclohexyl-, tert-butyl- and tert-amyl acetoacetate // Ukr. Khim. Zhurn., 2018, vol. 84, no. 3, pp. 13-19.

26. Dzyuba V.I., Koval L.I., Shtokvysh O.O., Trachevskyi V.V. , Pekhnyo V.I. Lipophilic chloro-oxo-bis(hydroxamato)-vanadium(V) complexes: synthesis methods and structure // Polyhedron - 2020. – V.180. – 114421 (https://doi.org/10.1016/j.poly.2020.114421)

27. Mishchuk O.O., Koval L.I., Dzyuba V.I., Pekhnyo V.I. Features of magnesium(II) bis-chelate complexes as environmentally friendly high-performance lubricating additives of new generation in the aspects of steel surface mechanochemistry // Dopov. Nats. Akad. Nauk. Ukr.. 2020. № 6: 83-91 (https://doi.org/10.15407/dopovidi2020.06.083.)

28. VV Povoroznyuk, NV Grigorieva, VI Pekhnyo, H Resch, OM Kozachkova, NV Tsaryk / Etidronic acid and its calcium-comprising complexes in the treatment of experimental osteoporosis in estrogen-deficient rats. // V.V. Povoroznyuk. Musculoskeletal diseases and age (selected publications in English): in 5 volumes. – Vol. 5. – K., 2019. – p. 295 -307

29. VV Povoroznyuk, NV Grigoreva, VI Pekhnyo, OM Kozachkova, NV Tsaryk / Zoledronic acid and its calcium-contain ing complexes in treatment of experimental osteoporosis in wistar female rats. // V.V. Povoroznyuk. Musculoskeletal diseases and age (selected publications in English): in 5 volumes. – Vol. 5. – K., 2019. – p. 281 -294

30. Povoroznyuk V.V., Pekhnyo V.I., Grigorieva N.V., Kozachkova O.M., Tsaryk N.V. Efficacy of bisphosphonic acids in female rats with experimental osteoporosis // V.V. Povoroznyuk Diseases of the musculoskeletal system in people of different ages (selected lectures, reviews, articles). Vol. 6. - K., 2019. - pp. 603 - 612

31. V.V. Povoroznyuk, V.I. Pekhnyo, N.V. Grigorieva, O.M. Kozachkova, N.V. Tsaryk / Efficiency of Bisphosphonic Acids in Female Rats with Experimental Osteoporosis. // International Journal of Physiology and Pathophysiology. - 2018. – v. 9. - №2. – р. 143-151

32. V.V. Dyakonenko, A.N. Kozachkova, N.V. Tsaryk, V.I. Pekhnyo and R.V. Lavryk / Bis-{ethylenediaminepalladium(II)}(methylenediphosphonate) hydrate. // Acta cryst. Section E. – 2018. – Е74. – 1838-1841

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